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CLC Cancer Research Workbench

Unraveling the complexity of Cancer. Expedite your understanding of cancer with CLC Cancer Research Workbench


Seeking the meaning of the sequence? Gain valuable insights into cancer with CLC Cancer Research Workbench!

  • Quickly analyze complex data
  • Modify or personalize workflows
  • Conveniently filter and visualize your data
  • Compare your results with relevant databases

The truth lurking behind the sequences…

Accelerate next-generation sequencing (NGS) data interpretation and uncover meaningful insights in cancer research with CLC Cancer Research Workbench — the world’s first comprehensive, user-friendly, and customizable cancer-focused informatics solution!

CLC Cancer Research Workbench provides you with all the tools you need to:

  • Discover prognostic markers
  • Identify subclonal somatic mutations
  • Detect inherited traits
  • Find biomarkers for drug response
  • Determine new oncogenes

Comprehensive analysis so you don’t miss a single detail!

To perform comprehensive cancer data analysis, CLC Cancer Research Workbench offers specialized tools that allow you to:

  • Remove germline variants
  • Identify rare subclonal mutations and mutated genes for further analysis
  • Annotate identified variants with information from COSMIC and ClinVar
  • Test the presence of specific variants
  • Compare samples and identify new biomarkers

Compare and share your data

Inspect identified variants in the context of mapped sequencing reads, human genes, and relevant variants in clinical databases, including:

  • Human genome
  • dbSNP
  • dbSNP common from UCSC
  • ClinVar
  • HapMap
  • 1000 genomes data
  • Ensembl genes

The intuitive software interface allows you to customise workflows or create new ones. You can also easily share workflows with your collaborators and colleagues.

End-to-end workflows for analysis of cancer data

Whether it is targeted amplicon, exome, or whole genome sequencing data, CLC Cancer Research Workbench is compatible with data generated using all sequencing platforms. From identifying known and novel variants with information from databases, amino acid changes, and conservation scores – versatile CLC Cancer Research Workbench provides comprehensive analysis to help you uncover all the details!


The looks

Latest improvements

We frequently release updates and improvements such as bug fixes, new features or plugins. To get a complete overview, please visit latest improvements .


System requirements

  • Windows Vista, Windows 7, Windows 8 or Windows Server 2008
  • Mac OS X 10.7 or later.
  • Linux: Red Hat 5.0 or later. SUSE 10.2 or later. Fedora 6 or later.
  • 8 GB RAM required
  • 16 GB RAM recommended
  • 1024 x 768 display required
  • 1600 x 1200 display recommended
  • Intel or AMD CPU required
  • Minimum 10 GB free disc space in the tmp directory
  • Minimum 80 GB free disc space required in the CLC_References directory (if you are not connected to a server). If you have less free disc space available it is possible to change the reference data location. How to do this is described in Download and configure reference data

  • Special requirements for read mapping. The numbers below give minimum and recommended memory for systems running mapping and analysis tasks. The requirements suggested are based on the genome size. Systems with less memory than specified below will benefit from installing the legacy read mapper plugin (see ). This is slower than the standard mapper but adjusts to the amount of memory available.
    • Human ( 3.2 gigabases) and Mouse ( 2.7 gigabases)
      • Minimum: 6 GB RAM
      • Recommended: 8 GB RAM


Need something bigger?

The underlying strategy of our enterprise platform is the smooth integration between desktop clients and our server back-end. As a user, you’re never confronted with scripts or advanced IT questions – you simply use your client as usual, and our platform takes care of all the analysis and data management in the background.

We provide an enterprise platform for building and managing a flexible and powerful sequence analysis setup in organizations of any size; from small biotech start-ups to large pharmaceutical or agricultural companies.

Check out CLC Cancer Research Server Solution for more information